PhoU domain (IPR026022)

Short name: PhoU_dom

Overlapping homologous superfamilies

Domain relationships



PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [PMID: 15716271]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect; suggesting that the protein has some secondary function [PMID: 8226621].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.