Histone-lysine N-methyltransferase, SET2, fungi (IPR025788)

Short name: Hist-Lys_N-MeTrfase_SET2_fun

Overlapping homologous superfamilies


Family relationships



This enzyme methylates histone H3 to form H3K36me. It is involved in transcription elongation as well as in transcription repression [PMID: 12736296, PMID: 16087749]. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent [PMID: 12736296, PMID: 11839797, PMID: 12629047, PMID: 12773564, PMID: 12917322, PMID: 15798214, PMID: 16227595]. It has been shown that this enzyme interacts with the RNA polymerase II hyperphosphorylated CTD and also with CYC8 in Saccharomyces cerevisiae [PMID: 12736296, PMID: 12629047, PMID: 12773564, PMID: 15798214, PMID: 12511561, PMID: 12381723, PMID: 16329992].

Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [PMID: 16225687, PMID: 21858014, PMID: 12826405]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [PMID: 7897657]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [PMID: 16225687, PMID: 21858014, PMID: 7897657]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [PMID: 16225687, PMID: 21858014, PMID: 12826405]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.

GO terms

Biological Process

GO:0006354 DNA-templated transcription, elongation
GO:0010452 histone H3-K36 methylation

Molecular Function

GO:0046975 histone methyltransferase activity (H3-K36 specific)

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles