Dual specificity phosphatase (IPR024950)

Short name: DUSP

Overlapping homologous superfamilies

Family relationships


Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [PMID: 17057753, PMID: 15186772]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. They are structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR [PMID: 8987394,PMID: 7961745,PMID: 8154323]. They are characterized as VHR- [PMID: 9571625,PMID: 8650541] or Cdc25-like [PMID: 7601801,PMID: 8701088].

In general, DUSPs are classified into the following subgroups [PMID: 19228121]:

  • Slingshot phosphatases
  • Phosphatase of regenerating liver (PRL)
  • Cdc14 phosphatases
  • Phosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatases
  • Mitogen-activated protein kinase phosphatases (MKPs)
  • Atypical DUSPs

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.