Octanoyltransferase LipM (IPR024898)

Short name: LipM

Overlapping homologous superfamilies


Family relationships



Lipoic acid is an organosulphur compound that is an essential coenzyme in several multienzyme complexes, including pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and the glycine cleavage system. Many Gram-positive bacteria, such as Bacillus subtilis, require three proteins for lipoic acid cofactor biosynthesis: LipJ, LipL and LipM [PMID: 21338420, PMID: 21338421]. LipM is a lipoate:protein ligase that transfers an octanoyl moiety from acyl-carrier protein to the GcvH protein of the glycine cleavage system. LipL, an octanoyltransferase, then transfers this moiety from GcvH to other enzyme complexes. LipA inserts the sulphur group to form the active lipoate cofactor.

This entry represents the LipM component of this system.

GO terms

Biological Process

GO:0009107 lipoate biosynthetic process
GO:0009249 protein lipoylation

Molecular Function

GO:0016415 octanoyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.