Transcription factor Maf family (IPR024874)

Short name: Transcription_factor_Maf_fam

Overlapping homologous superfamilies


Family relationships


Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors [PMID: 17569705]. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.