Transducer of regulated CREB activity, middle domain (IPR024784)

Short name: TORC_M

Overlapping homologous superfamilies


Domain relationships



This domain represents the region between the N and C terminus of TORC proteins. TORC (transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [PMID: 14536081]. Although the C- and N- terminal domains of the TORC proteins have been well characterised [PMID: 14536081, PMID: 14506290], no functional role has yet been assigned to the central region.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.