PurE, prokaryotic type (IPR024694)

Short name: PurE_prokaryotes

Overlapping homologous superfamilies

Family relationships



The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [PMID: 21548610]. Class I and class II PurEs are mechanistically related but bind different substrates.

This entry includes class I PurE (N5-CAIR mutase) mostly from bacteria and archaea. Interestingly, prokaryotic class II PurEs (AIR carboxylases) have been identified in Archaeoglobus fulgidus and Treponema denticola [PMID: 21548610]. They are included in this entry.

GO terms

Biological Process

GO:0006189 'de novo' IMP biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.