Homologous Superfamily

Argininosuccinate synthetase, catalytic/multimerisation domain body (IPR024074)

Short name: AS_cat/multimer_dom_body

Overlapping entries


The argininosuccinate synthetase (AS) monomer is composed of a nucleotide binding domain and a catalytic/multimerisation domain. The catalytic/multimerisation domain can be subdivided in the body of the domain and a C-terminal tail involved in multimerisation, though this tail is not presetn in all sequences.

This entry represents the body of the catalytic/multimerisation domain. It is a mixed alpha/beta fold consisting of two four-stranded antiparallel beta sheets arranged end-to-end to form a cradle for a cluster of five alpha helices. In general, the alpha helices of the domain are responsible for multimerisation interactions, whereas the beta sheets form the solvent-exposed surface [PMID: 11738042].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004055 argininosuccinate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.