Nucleoplasmin core domain (IPR024057)

Short name: Nucleoplasmin_core_dom

Overlapping homologous superfamilies

Domain relationships



This entry represents the core structural domain for the nucleoplasmin (Np) family of histone chaperone proteins. This core domain is formed by an 8-stranded beta barrel [PMID: 15576029].

The three branches of the Np family, including nucleophosmin (NO38/B23), nucleoplasmin (Np), and nucleoplasmin-like proteins (NLP), bind core histones and assemble nucleosomes in vitro assays. Even though they have different histone preferences, it has been suggested that Np family members may share a general mechanism for binding histones [PMID: 15576029].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.