Homologous Superfamily

AICAR transformylase, duplicated domain superfamily (IPR024051)

Short name: AICAR_Tfase_dup_dom_sf

Overlapping entries


This domain is found in the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC: (AICARFT). AICARFT can be part of a bifunctional enzyme catalysing the last two steps in de novo purine biosynthesis and having also an IMP (Inosine monophosphate) cyclohydrolase EC: (IMPCHase) functional domain. The bifunctional enzyme forms an intertwined dimer where each monomer is composed of two separate functional domains.

This superfamily represents a duplicated domain in AICARFT consisting of a three layer alpha-beta-alpha sandwich [PMID: 11323713].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.