Flavohemoprotein (IPR023950)

Short name: Hmp

Overlapping homologous superfamilies

Family relationships



This entry represents two-domain flavohemoproteins. These proteins have multiple enzymatic activities and consist of two distinct domains - an N-terminal heme- and oxygen-binding domain, and a C-terminal FAD and reductase domain. They display dihydropteridine reductase 2 activity, as well as functioning as nitric oxide dioxygenase [PMID: 11751864] and a ferrisiderophore reductase whereby the complexed Fe+3 iron of siderophores are reduced to Fe+2 and released [PMID: 10777548, PMID: 9724711,PMID: 1601132,PMID: 8022841].

Flavohemoproteins are found in bacteria and fungi. They are involved in the inducible response to nitrosative stress, as their nitric oxide dioxygenase ability is used in aerobic NO detoxification, a reaction which utilises O2 and NAD(P)H to convert NO to nitrate and therefore offers protection from various noxious nitrogen compounds [PMID: 10922365].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0051409 response to nitrosative stress

Molecular Function

GO:0071949 FAD binding
GO:0020037 heme binding
GO:0008941 nitric oxide dioxygenase activity
GO:0019825 oxygen binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.