N-acetylmannosamine kinase, bacterial (IPR023945)

Short name: ManNAc_kinase_bac

Overlapping homologous superfamilies


Family relationships

  • ROK family (IPR000600)
    • N-acetylmannosamine kinase, bacterial (IPR023945)


A family of bacterial proteins has been described which groups transcriptional repressors, sugar kinases and yet uncharacterised open reading frames [PMID: 7952186]. This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase EC: from Streptomyces coelicolor; fructokinase EC: from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase EC: and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.

This entry represent the bacterial N-acetylmannosamine kinase subfamily of the ROK family. Proteins in this entry catalyze the phosphorylation of N-acetylmannosamine(ManNAc) to ManNAc-6-P [PMID: 9864311],[PMID: 15157072],[PMID: 17979299].

GO terms

Biological Process

GO:0019262 N-acetylneuraminate catabolic process

Molecular Function

GO:0005524 ATP binding
GO:0009384 N-acylmannosamine kinase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.