Family

Glyoxylate reductase GyaR (IPR023519)

Short name: Glyoxylate_reductase_GyaR

Overlapping homologous superfamilies

Family relationships

None.

Description

The GyaR family of glyoxylate reductases catalyses the NADH-linked reduction of glyoxylate to glycolate. This family is found in hyperthermophilic archaea, where it is thought to play an important role in the glyoxylate and 3-hydroxypropionic acid cycles [PMID: 11532010]. Structurally, GyaR is similar to other NADH-linked dehydrogenases [PMID: 17327673]. The enzyme's thermostability appears to be due to the presence of aromatic clusters and the fact that it has more ion pairs and a relatively lower hydrophobic accessible surface area than mesophilic enzymes.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0047964 glyoxylate reductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP