Membrane insertase YidC/YidC1/YidC2, Firmicutes (IPR023060)

Short name: YidC/YidC1/YidC2_Firmicutes

Overlapping homologous superfamilies


Family relationships


This family includes membrane insertase YidC, YidC1 (also called MisCB), and YidC2 (also called MisCA). Members in this family are required for the insertion of integral membrane proteins into the membrane. They may also be involved in protein secretion processes.

Besides having the membrane insertase function, Bacillus MisCA is essential for sporulation by activating sigma factor SpoIIIG/SigG after engulfment is completed in the prespore, maybe by acting on SpoIIIAE. It has an overlapping, although partly distinct, function compared to YqjG(MisCB) [PMID: 1487728, PMID: 11889108, PMID: 12586834].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0032977 membrane insertase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.