Orotate phosphoribosyltransferase (IPR023031)

Short name: OPRT

Overlapping homologous superfamilies

Family relationships


Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. In the pyrimidine synthesis pathway, OPRT catalyses the reversible phosphoribosyl transfer from 5'-phospho-alpha-D-ribose 1'-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5'-monophosphate (OMP) [PMID: 22075667]. The structures and properties of the OPRTases from different species have been described in several publications [PMID: 12872993, PMID: 9305779, PMID: 8720144, PMID: 8487307].

GO terms

Biological Process

GO:0006221 pyrimidine nucleotide biosynthetic process

Molecular Function

GO:0004588 orotate phosphoribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.