Glucose-6-phosphate dehydrogenase, NAD-binding (IPR022674)

Short name: G6P_DH_NAD-bd

Overlapping homologous superfamilies

Domain relationships



Glucose-6-phosphate dehydrogenase (EC: (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [PMID: 2838391]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells [PMID: 3393536]. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [PMID: 3393536].

This entry represents the NAD-binding domain of glucose-6-phosphate dehydrogenase.

GO terms

Biological Process

GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0050661 NADP binding
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.