Conserved Site

Insulin, conserved site (IPR022353)

Short name: Insulin_CS


Insulin is involved in the regulation of normal glucose homeostasis, as well as other specific physiological functions [PMID: 6243748]. It is synthesised as a prepropeptide from which an endoplasmic reticulum-targeting sequence is cleaved to yield proinsulin. Prosinsulin contains regions A and B separated by an intervening connecting region C. The connecting region is cleaved, liberating the active protein, which contains the A and B chains, held together by 2 disulphide bonds [PMID: 503234].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns