CAS family, C-terminal (IPR021901)

Short name: CAS_C

Overlapping homologous superfamilies


Domain relationships



This domain is found in the C terminus of the CAS family members.

The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII [PMID: 19937461].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.