Cobalamin biosynthesis central region (IPR021745)

Short name: CbiG_mid

Overlapping homologous superfamilies

Domain relationships



Members of this family are involved in cobalamin synthesis. The gene encoded by P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [PMID: 9742225].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.