Shal-type voltage-gated potassium channels, N-terminal (IPR021645)

Short name: Shal-type_N

Overlapping homologous superfamilies


Domain relationships



This entry represents the N-terminal helical domain of the Shal-type voltage-gated potassium channels. This domain interact with Kv channel-interacting proteins to modulate cell surface expression and function of Kv4 channels. The interaction of the Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N-terminal alpha helix in Kv4.2 and a C-terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs [PMID: 14980206].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.