Erythronate-4-phosphate dehydrogenase (IPR020921)

Short name: Erythronate-4-P_DHase

Overlapping homologous superfamilies

Family relationships



Pyridoxal-5'-phosphate is the active form of vitamin B6 and is an essential cofactor for many enzymes, particularly those involved in amino acid metabolism [PMID: 15483325]. There are three known pathways for pyridoxal-5'-phosphate biosynthesis: the de novo pathway, the salvage pathway, and the fungal type pathway. Bacteria, fungi, parasites and plants all possess at least one of these pathways, but higher organisms, such as insects and mammals, are incapable of synthesising this compound and need vitamin B6 in their diet to survive.

Erythronate-4-phosphate dehydrogenase catalyses the first step in the de novo biosynthetic pathway, the oxidation of erythrose-4-phosphate to 4-phosphoerythronate [PMID: 9696782].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0008615 pyridoxine biosynthetic process

Molecular Function

GO:0033711 4-phosphoerythronate dehydrogenase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.