Arginine vasopressin-induced protein 1/transcriptional and immune response regulator (IPR020282)

Short name: Avpi1/C8orf4_dom

Overlapping homologous superfamilies


Domain relationships



This entry includes arginine vasopressin-induced protein 1 (Avpi1) and C8orf4 protein. Avpi1 is thought to be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling [PMID: 12356727]. C8orf4, also known as transcriptional and immune response regulator (TCIM) or thyroid cancer 1 (TC-1), plays important roles in many signalling pathways, such as Wnt/beta-catenin signalling pathway, and is involved in the development of many cancers [PMID: 25869879]. C8orf4 also suppresses NOTCH2 signalling in liver cancer stem cells [PMID: 25985737].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.