Conserved Site

Uricase, conserved site (IPR019842)

Short name: Uricase_CS


Uricase (EC: (urate oxidase) [PMID: 3182808] is the peroxisomal enzyme responsible for the degradation of urate into allantoin: Urate + O2 + H2O = 5-hydroxyisourate + H2O2 Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate [PMID: 2594778]. Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved. It is mainly localised in the liver, where it forms a large electron-dense paracrystalline core in many peroxisomes [PMID: 2338140]. The enzyme exists as a tetramer of identical subunits, each containing a possible type 2 copper-binding site [PMID: 2594778]. In legumes, 2 forms of uricase are found: in the roots, the tetrameric form; and, in the uninfected cells of root nodules, a monomeric form, which plays an important role in nitrogen-fixation [PMID: 16593585].

The signature pattern used to create this entry covers a highly conserved region located in the central part of the sequence.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006144 purine nucleobase metabolic process

Molecular Function

GO:0004846 urate oxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns