Pyruvate/ketoisovalerate oxidoreductase, catalytic domain (IPR019752)

Short name: Pyrv/ketoisovalerate_OxRed_cat

Overlapping homologous superfamilies

Domain relationships


This domain is found in prokaryotes. It includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms [PMID: 8550425]. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA [PMID: 8550425]. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [PMID: 8415612].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.