CBF1-interacting co-repressor CIR, N-terminal domain (IPR019339)

Short name: CIR_N_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents a 45 residue conserved domain found at the N-terminal end CIR protein (CBF1-interacting co-repressor, also known as corepressor interacting with RBPJ 1). This domain can be found in the fungal CWC25 family members and mammlian LENG1 (leukocyte receptor cluster member 1) protein.

CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [PMID: 9874765]. CIR also plays a role in alternative splicing [PMID: 15652350].

Budding yeast Cwc25 is a pre-mRNA-splicing factor involved in pre-mRNA splicing [PMID: 14690591].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.