Conserved Site

SAICAR synthetase, conserved site (IPR018236)

Short name: SAICAR_synthetase_CS


Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC: (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [PMID: 1574589, PMID: 15641804].

In bacteria (purC), fungi (ADE1) and plants (Pur7), SAICAR synthetase is a monofunctional protein; in animals it is the N-terminal domain of a bifunctional enzyme that also catalyse phosphoribosylaminoimidazole carboxylase (AIRC) activity (see IPR000031).

GO terms

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns