Conserved Site

GTP cyclohydrolase I, conserved site (IPR018234)

Short name: GTP_CycHdrlase_I_CS


GTP cyclohydrolase I (EC: catalyses the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. The comparison of the sequence of the enzyme from bacterial and eukaryotic sources shows that the structure of this enzyme has been extremely well conserved throughout evolution [PMID: 7542887].

GO terms

Biological Process

GO:0046654 tetrahydrofolate biosynthetic process

Molecular Function

GO:0003934 GTP cyclohydrolase I activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns