Binding Site

Superoxide dismutase, copper/zinc, binding site (IPR018152)

Short name: SOD_Cu/Zn_BS


Copper/Zinc superoxide dismutase (SODC) [PMID: 3315461] is one of the three forms of an enzyme that catalyzes the dismutation of superoxide radicals. SODC binds one atom each of zinc and copper. Various forms of SODC are known: a cytoplasmic form in eukaryotes, an additional chloroplast form in plants, an extracellular form in some eukaryotes, and a periplasmic form in prokaryotes. The metal binding sites are conserved in all the known SODC sequences [PMID: 556751].

This entry contains 2 patterns, the first contains the two histidine residues that bind the copper atom; the second one is located in the C-terminal section of SODC and contains a cysteine which is involved in a disulphide bond. These patterns will not detect proteins related to SODC, but which have lost their catalytic activity, such as Vaccinia virus protein A45.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004784 superoxide dismutase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns