Thymidylate kinase (IPR018094)

Short name: Thymidylate_kinase

Overlapping homologous superfamilies

Family relationships



Thymidylate kinase (EC:; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:

ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate

Thymidylate kinase is an ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages [PMID: 8024690].

GO terms

Biological Process

GO:0006233 dTDP biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0004798 thymidylate kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.