Conserved Site

Glycoside hydrolase, family 5, conserved site (IPR018087)

Short name: Glyco_hydro_5_CS


O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 5 GH5 comprises enzymes with several known activities; endoglucanase (EC:; beta-mannanase (EC:; exo-1,3-glucanase (EC:; endo-1,6-glucanase (EC:; xylanase (EC:; endoglycoceramidase (EC:

The microbial degradation of cellulose and xylans requires several types of enzymes. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family A [PMID: 2806912] or as the glycosyl hydrolases family 5 [PMID: 1747104]. One of the conserved regions in this family contains a conserved glutamic acid residue which is potentially involved [PMID: 1677466] in the catalytic mechanism.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns