Conserved Site

Ribosomal protein S4, conserved site (IPR018079)

Short name: Ribosomal_S4_CS


Ribosomal protein S4 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S4 is known to bind directly to 16S ribosomal RNA. Mutations in S4 have been shown to increase translational error frequencies. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [PMID: 2041737], groups:

  • Eubacterial S4.
  • Algal and plant chloroplast S4.
  • Cyanelle S4.
  • Archaebacterial S4.
  • Mammalian S9.
  • Yeast YS11 (SUP46).
  • Marchantia polymorpha (Liverwort) mitochondrial S4.
  • Dictyostelium discoideum (Slime mold) rp1024.
  • Yeast protein NAM9 [PMID: 1729612]. NAM9 has been characterised as a suppressor for ochre mutations in mitochondrial DNA. It could be a ribosomal protein that acts as a suppressor by decreasing translation accuracy.

S4 is a protein of 171 to 205 amino-acid residues (except for NAM9 which is much larger).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019843 rRNA binding

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns