Conserved Site

CXC chemokine, conserved site (IPR018048)

Short name: Chemokine_CXC_CS


Most members of this family of low-molecular weight proteins seem to have mitogenic, chemotactic or inflammatory activities. They are released by phagocytes, mesenchymal cells and a wide variety of tissue cells, upon exposure to inflammation [PMID: 1639201]. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds.

The family can be split into two groups, depending on the spacing of two N-terminal Cys residues: in one group (CxC), the cysteines are separated by a single amino acid; in the second (C-C), they are adjacent [PMID: 2523801]. The CxC group includes such factors as interleukin-8, platelet factor 4, melanoma growth stimulatory activity protein, macrophage inflammatory protein 2, platelet basic protein, and several others. The 'C-C' group includes the monocyte chemotactic proteins, macrophage inflammatory proteins, amongst others.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns