RNA 3'-terminal phosphate cyclase type 1 (IPR017770)

Short name: RNA3'_term_phos_cyc_type_1

Overlapping homologous superfamilies

Family relationships


RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases (EC: [PMID: 9184239, PMID: 2199762] catalyse the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA:

ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

The physiological function of the cyclase is not known, but the enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclisation of the 3' end of U6 snRNA [PMID: 9184239].

A second subfamily of RNA 3'-terminal phosphate cyclases (type 2) that do not have cyclase activity have been identified in eukaryotes. They are localised to the nucleolus and are involved in ribosomal modification [PMID: 10790377].

This entry represents the type 1 RNA 3'-terminal phosphate cyclases.

GO terms

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003963 RNA-3'-phosphate cyclase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.