Formyl-CoA:oxalate CoA-transferase (IPR017659)

Short name: Formyl_CoA_transfer

Overlapping homologous superfamilies

Family relationships


CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism:

  • Family I consists of CoA-transferases for 3-oxoacids (EC:, EC:, short-chain fatty acids (EC:, EC: and glutaconate (EC: Most use succinyl-CoA or acetyl-CoA as CoA donors.
  • Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase (EC:, EC: These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well.
  • Family III consists of formyl-CoA:oxalate CoA-transferase [PMID: 15213226], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [PMID: 11418570], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [PMID: 10849007], and butyrobetainyl-CoA:(R)-carnitine CoA-transferase [PMID: 15823031]. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [PMID: 11749953].

Family III CoA-transferase family member formyl-CoA transferase transfers coenzyme A from formyl-CoA to oxalate. It forms a pathway, together with oxalyl-CoA decarboxylase, for oxalate degradation; decarboxylation by the latter gene regenerates formyl-CoA. The two enzymes typically are encoded by a two-gene operon [PMID: 16517636].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0033608 formyl-CoA transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.