Eukaryotic elongation factor 2 kinase (IPR017400)

Short name: eEF-2K

Overlapping homologous superfamilies


Family relationships



This entry represents elongation factor 2 kinase (eEF-2 kinase), a highly specific kinase that phosphorylates and inactivates eukaryotic elongation factor-2 (eEF-2), and thus can modulate the rate of polypeptide chain elongation during translation. eEF-2 kinase is part of the family of alpha-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases [PMID: 11904175]. This family also includes Dictyostelium myosin heavy chain kinases A, B, and C, and several mammalian putative protein kinases.

The domain organisation of eEF-2 kinase appears to consist of two domains connected by a linker region, where the N-terminal domain contains the catalytic site, and the C-terminal domain contains the eEF-2 target region. The calmodulin-binding region is located between residues 51 and 96 [PMID: 11015200].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0004686 elongation factor-2 kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.