Ras-related small G protein, RGK family (IPR017358)

Short name: RGK

Overlapping homologous superfamilies

Family relationships


This entry includes Rad, Rem, Rem2, and Gem/Kir. They belong to the Ras superfamily of monomeric G-proteins. They are the most potent known intracellular inhibitors of high-voltage-activated Ca2+(Ca(V)1 and Ca(V)2) channels [PMID: 23063948]. Similar to other Ras superfamily proteins, RGKs contain a guanine nucleotide binding domain (G-domain). However, they have non-conservative substitutions in the G-domain of residues critical for GTP binding and hydrolysis [PMID: 23063948].

GO terms

Biological Process

GO:1901842 negative regulation of high voltage-gated calcium channel activity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.