BTB-kelch protein (IPR017096)

Short name: BTB-kelch_protein

Overlapping homologous superfamilies

Family relationships


Proteins in this family contain an N-terminal BTB domain and the C-terminal Kelch motifs. The BTB/POZ domain facilitates protein binding. The Kelch motif is a 50-residue motif named after the Drosophila mutant in which it was first identified [PMID: 8453663]. This sequence motif represents one beta-sheet blade, and several of these repeats can associate to form a beta-propeller. Some members in this family also contain a BACK domain, which is a conserved 130-residue region between the BTB domain and Kelch motifs[PMID: 15544948]. BTB-kelch protein family includes KLHL and part of the KBTBD subfamilies, which encompass structurally related molecules that differ in the types and numbers of their protein domains.

KBTBD subfamily typically possess a BTB and BACK domain and two to four Kelch motifs [PMID: 23676014]. It's worth noting that not all the KBTBD subfamily members are in this entry.

KLHL subfamily members generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs [PMID: 23676014]. Gigaxonin is one of the KLHL subfamily members. It binds to the ubiquitin-activating enzyme E1 through its N-terminal BTB domain and its six C-terminal kelch repeat domain interacts directly with the light chain (LC) of microtubule-associated protein 1B (MAP1B) [PMID: 16227972, PMID: 12147674].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.