Transcriptional adaptor 2 (IPR016827)

Short name: Ada2/TADA2

Overlapping homologous superfamilies


Family relationships


This entry represents a group of transcriptional adaptors, including transcriptional adapter 2 (TADA2) from animals and plants, and Ada2 from yeasts.

Ada2 is a component of the SAGA/ADA coactivator complex, which regulates numerous cellular processes by coordinating histone acetylation [PMID: 11777910, PMID: 19279142].

There are two Drosophila Ada2 homologues, dAda2a and dAda2b. dAda2b is a component of Spt-Ada-Gcn5-acetyltransferase (SAGA) complexes, while dAda2a associates with dGcn5 but is not incorporated into dSAGA-type complexes [PMID: 12697829].

Mammalian TADA2 is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The ATAC complex is involved in mammalian development, histone acetylation, cell cycle progression, and prevention of apoptosis during embryogenesis [PMID: 19103755].

GO terms

Biological Process

GO:0035065 regulation of histone acetylation
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.