Phosphoacetylglucosamine mutase (IPR016657)

Short name: PAGM

Overlapping homologous superfamilies

Family relationships



This group represents a phosphoacetylglucosamine mutase (PAGM; also known as phosphoglucomutase 3 or N-acetylglucosamine-phosphate mutase [PMID: 12174217]). It is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into GlcNAc-1-phosphate as part of the UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthetic pathway. UDP-GlcNAc is an essential metabolite that serves as the biosynthetic precursor of many glycoproteins and mucopolysaccharides. PAGM is a member of the alpha-D-phosphohexomutase superfamily [PMID: 16651269], which catalyzes the intramolecular phosphoryl transfer of sugar substrates [PMID: 17548465]. The alpha-D-phosphohexomutases have four domains with a centrally located active site formed by four loops, one from each domain [PMID: 11004509]. All four domains are included in this alignment model.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004610 phosphoacetylglucosamine mutase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.