Prefoldin subunit 3 (IPR016655)

Short name: PFD3

Overlapping homologous superfamilies

Family relationships


Prefoldin subunit 3 (PFD3, also known as VBP-1) is part of the heteromeric co-chaperone complex, which delivers unfolded proteins to cytosolic chaperonin and acts as a cofactor. PFD3 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding [PMID: 9630229]. In fruit flies PFD3 (also known as mgr) interacts with von Hippel Lindau protein (Vhl) and betaTub56D/tubulin beta-1 chain. It is required for tubulin stability and spindle and centrosome formation in cooperation with Vhl [PMID: 22451918].

GO terms

Biological Process

GO:0006457 protein folding

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016272 prefoldin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.