Homologous Superfamily

FAD/NAD-linked reductase, dimerisation domain superfamily (IPR016156)

Short name: FAD/NAD-linked_Rdtase_dimer_sf

Overlapping entries


This superfamily represents a dimerisation domain that is usually found at the C-terminal of FAD and NAD-linked reductases. This domain has a core alpha+beta sandwich structure consisting of beta(3,4)-alpha(3). The first two domains are of the same beta/beta/alpha fold. This domain can be found in the following proteins:

  • Glutathione reductase [PMID: 9546215].
  • Trypanothione reductase [PMID: 8771196].
  • Mammalian thioredoxin reductase [PMID: 11481439].
  • Apoptosis-inducing factor (AIF), which contains a large loop insertion in this domain [PMID: 12198487].
  • NADH peroxidase [PMID: 7766608].
  • Biphenyl 2,3-dioxygenase, ferredoxin reductase (also known as NADH-dependent ferredoxin reductase, BphA4) [PMID: 11090282].
  • Putidaredoxin reductase [PMID: 15095867].
  • Dihydrolipoyl dehydrogenase (also known as dihydrolipoamide dehydrogenase) [PMID: 8805537].
  • 2-oxopropyl-CoM reductase, carboxylating (also known as NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase) [PMID: 12390015].
  • The flavin-binding subunit of flavocytochrome c sulphide dehydrogenase (FCSD) [PMID: 7939681].
  • NADH oxidase /nitrite reductase.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0050660 flavin adenine dinucleotide binding
GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.