Family

Cytolethal distending toxin A (IPR015957)

Short name: CDtoxinA

Overlapping homologous superfamilies

Family relationships

Description

Escherichia coli, Haemophilus spp and Campylobacter spp. all produce a toxin that is seen to cause distension in certain cell lines [PMID: 8112838, PMID: 10203548], which eventually disintegrate and die. This novel toxin, termed cytolethal distending toxin (cdt), has three subunits: A, B and C. Their sizes are approx. 27.7, 29.5 and 19.9kDa respectively [PMID: 8112838], and they appear to be entirely novel [PMID: 10203548].

Further research on the complete toxin has revealed that it blocks the cell cycle at stage G2, through inactivation of the cyclin-dependent kinase Cdk1, and without induction of DNA breaks. This leads to multipolar abortive mitosis and micronucleation, associated with centrosomal amplification [PMID: 10777111]. The roles of each subunit are unclear, but it is believed that they have separate roles in pathogenicity.

This entry represents the A subunit.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PRINTS