Domain

L-fucose isomerase, C-terminal (IPR015888)

Short name: Fuc_isomerase_C

Overlapping homologous superfamilies

Domain relationships

None.

Description

L-fucose isomerase (EC:5.3.1.25) converts the aldose L-fucose into the corresponding ketose L-fuculose during the first step in fucose metabolism using Mn2+ as a cofactor. The enzyme is a hexamer, forming the largest structurally known ketol isomerase, and has no sequence or structural similarity with other ketol isomerases. The structure was determined by X-ray crystallography at 2.5 A resolution [PMID: 9367760].

This entry represents the C-terminal domain of L-fucose isomerase.

GO terms

Biological Process

GO:0006004 fucose metabolic process

Molecular Function

GO:0008736 L-fucose isomerase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam