T-cell surface antigen CD2 (IPR015632)

Short name: CD2

Overlapping homologous superfamilies

Family relationships



The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation [PMID: 12475217]. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. CD2 knockout mice exhibit essentially normal immune function [PMID: 1358605], and it is thought that CD2 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 [PMID: 9794375].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.