Peptidase M14B, caboxypeptidase D (IPR015567)

Short name: Pept_M14B_carboxypept_D2

Overlapping homologous superfamilies


Family relationships



Metallocarboxypeptidase D (MEROPS identifier XM14-001) is a compound peptidase consisting of a single-chain protein that contains three metallocarboxypeptidase-like units (MEROPS identifiers M14.011, M14.016 and M14.950), each of about 390 amino acid residues [PMID: 10506132, PMID: 9355738]. The first two metallocarboxypeptidase units are catalytically active, while the third homologous unit is more divergent in sequence, and lacks several of the residues thought to be essential for catalytic activity. The C-terminal cytosolic tail of metallocarboxypeptidase D appears to direct retention of the protein in the trans-Golgi network. Variations in structure in this region give rise to forms that are soluble [PMID: 10329672].

This entry represents the caboxypeptidase D found in metazoans and its homologue found in plants carboxypeptidase SOL1.

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004181 metallocarboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.