Antithrombin-III (IPR015555)

Short name: AT-III

Overlapping homologous superfamilies

Family relationships


Antithrombin-III (AT-III), also known as serpin C1, is the most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits serine proteases of the intrinsic coagulation pathway such as thrombin and factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin [PMID: 6693405, PMID: 15853774, PMID: 2126464]. It also inhibits matriptase-3/TMPRSS7; this inhibition seems to be lost in the majority of carcinoma cells [PMID: 15853774, PMID: 21795523].

This entry corresponds to the antithrombin full-length sequence.

GO terms

Biological Process

GO:2000266 regulation of blood coagulation, intrinsic pathway

Molecular Function

GO:0008201 heparin binding
GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.