Glypican-3 (IPR015501)

Short name: Glypican-3

Overlapping homologous superfamilies


Family relationships

  • Glypican (IPR001863)
    • Glypican-3 (IPR015501)


Glypicans [PMID: 8589707, PMID: 7657705] are a group of heparan sulphate proteoglycans which are anchored to cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Structurally, these proteins consist of three separate domains:

  • a) A signal sequence;
  • b) An extracellular domain of about 500 residues that contains 12 conserved cysteines probably involved in disulphide bonds and also contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;
  • c) A C-terminal hydrophobic region that is post-translationally removed after formation of the GPI-anchor.

Six members (GPC1-6) are known in vertebrates [PMID: 11474185]. GPC3 encodes a putative extracellular proteoglycan, glypican 3 that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. Initial western- and ligand-blotting experiments suggest that glypican 3 forms a complex with insulin-like growth factor 2 (IGF2), and might thereby modulate IGF2 action [PMID: 8589713]. GPC3 gene defects in a wider range of overgrowth disorders [PMID: 9192268]. GPC3 shares a number of features with the GPC1 [PMID: 3185547].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.