Glycoside hydrolase family 38, central domain (IPR015341)

Short name: Glyco_hydro_38_cen

Overlapping homologous superfamilies

Domain relationships



This entry represents a domain found in members of the glycosyl hydrolases families 38. This domain is found in the central region that adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase [PMID: 12634058].

Glycoside hydrolase family 38 GH38 comprises enzymes with only one known activity; alpha-mannosidase (EC: (EC:

Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. The enzyme catalyses the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.

GO terms

Biological Process

GO:0006013 mannose metabolic process

Molecular Function

GO:0004559 alpha-mannosidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.