Homologous Superfamily

DNA-binding pseudobarrel domain superfamily (IPR015300)

Short name: DNA-bd_pseudobarrel_sf

Overlapping entries


This superfamily represents a DNA recognition domain found in the restriction endonuclease EcoRII and numerous transcription factors. The EcoRII structure has been studied and forms an eight-stranded beta-sheet with the strands in the order of b2, b5, b4, b3, b7, b6, b1 and b8. The strands are mostly antiparallel to each other except that b3 is parallel to b7. Alternatively, it may also be viewed as consisting of two mini beta-sheets of four antiparallel beta-strands, sheet I from beta-strands b2, b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into an open mixed beta-barrel with a novel topology. Sheet I has a simple Greek key motif while sheet II does not [PMID: 14659759].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.