NSP8 replicase (IPR014829)

Short name: NSP8

Overlapping homologous superfamilies

Domain relationships



Viral Nsp8 (non structural protein 8) forms a hexadecameric supercomplex with Nsp7 that adopts a hollow cylinder-like structure [PMID: 16228002]. The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase [PMID: 16228002].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.